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Two major thoroughfares intersect in Hinds County: Interstate 20 (running east and west from Texas to South Carolina) and Interstate 55 (running north and south from Illinois through Louisiana). A third artery, Interstate 220, connects Interstate 20 west of Jackson and Interstate 55 north of Jackson.

United States Highways 49, 51, and 80 also intersect in Jackson and connect Hinds County with the Gulf of Mexico and the contiguous states of Alabama, Arkansas, Louisiana, and Tennessee.

City State Distance (mi) Distance (km) Travel Time Via
New Orleans Louisiana 186 299 2 hours, 40 minutes I-55 (S)
Memphis Tennessee 210 338 2 hours, 52 minutes I-55 (N)
Mobile Alabama 191 307 3 hours, 1 minute Highway 49 (S)
Birmingham Alabama 237 381 3 hours, 21 minutes I-20 (E)
Atlanta Georgia 381 613 5 hours, 20 minutes I-20 (E)
Dallas Texas 402 647 5 hours, 39 minutes I-20 (W)
Nashville Tennessee 415 668 5 hours, 43 minutes I-55 (N)
Houston Texas 441 710 6 hours, 10 minutes I-55 (S)
St. Louis Missouri 491 790 7 hours, 5 minutes I-55 (N)